Eötvös Loránd Tudományegyetem
Természettudományi Kar
Fizikai Intézet







mesterszakos diplomatéma részletei


A kiíró adatai
Név: Szöll?si Gergely János
Tudományos fokozat: PhD
Intézet: Fizika Intézet, Biológiai Fizika Tanszék 1117 Pázmány Péter stny. 1A
Telefonszám: 06307253532
Honlap: http://angel.elte.hu/~ssolo


A mesterszakos diplomatéma:
Címe: The balance between proliferation and differentiation determines neoplastic progression in hierarchically organized tissues
A munka jellege: elméleti
Szakterületi besorolás: Biológiai Fizika
A téma rövid leírása: Cancer is a genetic disease fuelled by somatic evolution. Despite advances in the molecular biology of cancer associated genes and the recent surge in the amount of DNA sequences available for different cancers, our understanding of the evolutionary mechanisms that lead to cancer is limited and cancer mortality rates have changed little in the last few decades. Until we unravel cancer"s basic principles, the battle against it can only progress in inches, rather than in miles.

To address the problems quantitatively, a new field called the physics of cancer has emerged. In the context of this emerging field the Evolutionary Genomics Research Group works to understand the evolutionary process that leads to the breakdown of the hierarchical organisation of healthy tissues and the emergence of tumours, using evolutionary models, computer simulations, and sequence analysis. We do this with the aim of developing models that can predict how cancers respond to treatment depending on their functional and genetic diversity and guide us toward developing novel treatment strategies and improving existing ones. In our most recent work (Derenyi and Szollosi 2017, we asked how tissues generate large numbers of cells while at the seam time minimising the accumulation of mutations and the risk of cancer.
To answer the question we introduced a general model of hierarchically organised self-renewing tissue and derived the lower limit of lifetime divisional load of a tissue. We showed that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy. We are looking for a postdoctoral researcher to build on these results and work with us in exploring the evolutionary process that lead to breakdown of hierarchical organisation of healthy tissues. The questions that we want to answer include: Under what conditions do hierarchically differentiated tumours, i.e. cancer stem cells, evolve? Which kind of mutation lead to cancer and in what combination, e.g. do mutations that increase symmetric vs. asymmetric cell division rate drive tumour progression or vice versa?

Derenyi, I and Szollosi, GJ Hierarchical tissue organization as a
general mechanism to limit the accumulation of somatic mutations
Nature Communications 14545, 2017
Szükséges előismeretek: statistical physics and programming
Egyetemi konzulens:




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